Clinical Studies
In recent years, the use of NMR Spectroscopy has become increasingly widespread in the field of clinical studies. Progression of therapy can now be documented by observing a change in concentration of certain metabolites found in body fluids or cell systems. Moreover, multi-component analyses can be performed, thereby making it possible to detect the appearance of abnormal metabolic products more rapidly and accurately than by other conventional methods.
The above figure shows a comparison of intensities taken from a clinical study on the treatment of diabetes mellitus II. The spectra show the time-dependent reduction of 13C labelled glucose with a simultaneous increase in lactate. Such tests can be used to observe the effects of drugs directly.
Many diseases cause an increase or decrease in the concentration of certain metabolites. INFAI can directly determine this change in the concentration of metabolites qualitatively and, in most instances, quantitatively using NMR spectra of urine or serum. Thus the effect of a particular drug used for treatment can be observed quickly and at low costs.